Lopez, 37, became a dad for the first time in September when his girlfriend Courtney Mazza gave birth to their daughter Gia Francesca.
Speaking on The Ellen DeGeneres Show, Lopez said: 'I definitely want more kids. I'd love three or four, to be honest.'
However Mazza isn't so sure.
He added: 'She's like, one at a time. She's cool with that. She definitely wants them, but I kind of want them right away, and that's where we have our differences.'
Lopez said he thinks it's better when brothers and sisters are closer in age.
He said: 'I was raised close in age. When there is too much of a gap... I don't know, I just think it would be cooler.'