The film is being directed by Alex Kurtzman and it will also star Chris Pine, Elizabeth Banks and Olivia Wilde, according to Variety.
Pfeiffer, 52, will play the role of the mother of a young businessman, played by Pine, who returns to his family home after his estranged father's death.
He then finds out he has an older sister, played by Elizabeth Banks, that he never knew about as well as a young nephew.
Wilde, 26, will play the role of Pine's girlfriend in the film, which is set to start shooting later this month.