The 'Torn' hitmaker – who narrates a new anti-fur video released by animal rights organisation People for the Ethical Treatment of Animals (PETA) – has urged fashion lovers to turn their backs on animal skins, insisting it is a brutal and inhumane trade.
She said: "There is no kind way to rip the skin off animals' backs. Anyone who wears any fur shares the blame for the torture and gruesome deaths of millions of animals each year
"Saving animals is as simple as choosing synthetic alternatives instead of real fur."
Natalie is not the first star to back PETA's anti-fur campaign, with supporters including Simon Cowell, Eva Mendes, Kate Winslet and Charlize Theron.
However, many other famous faces have risked the wrath of the organisation by continuing to don fur garments.
Naming Catherine Zeta-Jones as their Worst Dressed star last year, PETA released a statement saying: "With her cow-skin pants, ugly fox coat and icky alligator bag, Catherine Zeta-Jones looks like she's working her way through Noah's ark with a knife.
"Maybe she's trying to get into character for an upcoming role as a serial killer - or a taxidermist."
PETA have also had harsh words for singer-and-actress Jessica Simpson - whose transition into country music flopped last year.
The group said of her outfits: "All resemble her career - dead."