The US band will be playing a gig at Koko in Camden, London, on September 2 and it will be hosted by the Radio One DJ Zane Lowe.
The show will be the band's first in the UK for four years and it is taking place just two months before their tour kicks off in November.
Tickets for the gig are free and 502 pairs will be up for grabs through the Radio One website.
Fans can register on the website until Sunday 21 August 2011.
Speaking about the show, host Zane Lowe said: 'The Chili Peppers have played such a big musical role in the lives of millions of people, myself included.
'I can't wait to see how they launch this new chapter in their amazing journey.'