Katy Perry's husband became the latest in a long line of celebrities honoured with a coveted appearance in the long-running Fox animated series.
Also featuring in Sunday night's episode - called Angry Dad: The Movie - were Hollywood beauty Halle Berry, Curb Your Enthusiasm actor JB Smoove and Wallace and Gromit creator Nick Park.
Ricky Gervais, who fell for Marge in a previous episode based on the series Wife Swap, returned to voice his character for the show once again.
Boasting about his celebrity status a bartender, he joked about fellow awards ceremony guests, even calling legendary actress Helen Mirren 'fur coat, no knickers'.
When Brand's character presents the Golden Globe award for Bart's film, a delighted Homer gatecrashes the podium and gives his own acceptance speech.
In his true controversial style, a deadpan Brand told the celebrity-filled audience: 'It's great to be here with all the old friends I haven't seen since rehab. Just kidding, none of you are my friends.'
Characters Lady Gaga and Elton John appeared less than amused as they sat in the audience.
The movie's winning streak continued with Homer taking credit at each awards ceremony - so when Angry Dad received an Oscar nomination, Bart decided to keep it a secret.
But Homer and Marge arrived at the glittering ceremony just as Berry slinked on stage to present the all-important Academy Award.
Halle’s character even donned the see-through Elie Saab gown she wore when accepting her own 2002 Oscar for her part in Monster's Ball.
Bart's fellow nominee Park then helps him realise creating a film is a team effort, and humble Bart gives credit where credit is due.