The 77-year-old artist has long been thought of as the reason behind the disintegration of the band, which was fronted by her late husband John Lennon.
But talking to the Daily Mail, Ono insisted that she did not have enough power to force such a split.
She explained, 'The Beatles were a group made up of four very complex men, and my small hand could not have broken these men up. They broke up because they had reached an end, but in doing so they all also created new wonderful beginnings.'
She added that the rift between herself and Lennon's former best friend and co-writer Paul McCartney has also healed over the years.
'Paul has a very sweet side and he and I have made our peace,' she said. 'We are both business partners in Apple, and we speak and things are good between us.
'We know each other very well, and while we've had differences in the past, there was never a rift as people think. It was never so black and white.'