The 35-year-old rapper was signed by Eminem's Shady Records after releasing three mixtapes in 2002, and went on to release his Dr Dre-produced debut single, In The Club.
Since then, he has always released a 'street single' version of a track first, and promoted it on urban radio stations like New York's Hot 97 in a bid to warm fans up ahead of the release of a more radio-friendly version, whereas the bigger acts just head straight for the charts.
He told MTV News, 'When you say Lady Gaga, a pop artist, they want them to just deliver a song, They don't have the mixshow radio platform to go through before they would actually go for adds on an actual record.
'Her (Lady Gaga) records go to top 40 and crossover radio immediately. You can't really compare it to any artist that would be considered a pop artist or a white artist. And I say that openly, because what we consider urban radio or rhythmic radio was referred to as black radio at one point. That right there is something that I am conscious of.'
'You can't compare Eminem and 50 Cent's career on any level.
'Eminem doesn't know what the inside of Hot 97 looks like. He's never even had to go there.'