The US rapper is a huge fan of the 'Britain's Got Talent' runner-up – whose debut album 'I Dreamed A Dream' has topped the album charts in both the UK and US – and would like to duet with her.
He said: "She's got an amazing voice, and together we'd get everyone dancing. I'm always looking to do something new and she's cool, so I'll ask somebody to let her know."
The hip-hop star says Susan is "hot right now" and has guaranteed the pair would "make a hit".
He added to Britain's Daily Mirror newspaper: "I got to get her on a track, for real. We'd make a hit."
50 Cent is not the only celebrity fan Susan has.
Seal has given the 48-year-old 'Wild Horses' singer his backing and believes she is a true artist.
The 'Kiss From A Rose' singer - who is married to model Heidi Klum – said: "She sings because it's her form of expression and if she doesn't she will become ill. It's her way of release."