The US group, who played the huge half-time show at the Super Bowl last night, will play the event in Hyde Park on July 1.
Dance duo The Chemical Brothers will top the bill on the Saturday night.
Sunday's big act, Pulp, who are set to reform after many years, were announced late last year.
The Wireless Festival will be the only British festival appearance that the Black Eyed Peas, featuring Fergie and Will.I.Am, will perform at.
They will be joined by top UK artists including Plan B and Tinie Tempah.