The 41-year-old Welsh actress, who now lives in America with husband Michael Douglas and their two children, has been announced as the winner of the 2011 William R Hopkins medal.
According to YoungHollywood.com, the star will be presented with the award by the St David's Society of the State of New York.
The University of Wales's Dylan Thomas Prize founder Peter Stead said, 'I am absolutely thrilled Catherine is being given this honour by the St David's Society of the State of New York.
'She has done such a lot to promote Wales and the Welsh around the world through her work. But she is also an active supporter of charities and other causes including the arts and her role as a backer of the Dylan Thomas Prize has been a pivotal one.'
Stead added, 'She thoroughly deserves to be honoured by New Yorkers who are either Welsh or have Welsh backgrounds. I'm told by the organisers Michael Douglas will be with her and I'm sure everyone will be pleased to see him. It promises to be a great night of celebrating Welshness in the heart of one of the most influential cities in the world.'