Sheen, who shared the screen with Cryer on Two and a Half Men, branded the actor a “troll” and a “traitor” and slammed him for not reaching out to him.
“Jon has not called me,” he told a US website. “He’s a turncoat, a traitor, a troll. Clearly he’s a troll.
“Is it going to take me calling him a ‘traitor, juvenile and scared’ for him to get it?
“Like I said, you’re with me or you’re with the trolls,” he added. “Obviously he’s with the trolls.”
Sheen’s criticisms of Cryer came just 24 hours after he was sacked from his role on Two and a Half Men.
Producers and Warner Bros Television announced they were getting rid of the former Spin City star following his tirades against his bosses and the show’s producer Chuck Lorre.
Asked how he would react if Cryer took the time to reach out now, Sheen said: “What’s there to say? I’ll tell him, ‘You’re a little late. Goodbye troll’.
“When I’m starring in multi-million dollar films and he’s begging me for a supporting role, I’ll say, ‘You left me out in the cold with all of your guilt and stupidity’.”