The host was halfway through interviewing US entrepreneur Mark Cuban when Charlie burst in, swore at the audience, and landed a fat kiss on Kimmel's lips.
'I can't stay, I can't stay, I got a show to write god damn it,' said Charlie before offloading a bag of 'winning' and 'tiger blood' merchandise in the crowd.
'How are you, are you getting enough sleep?' asked Kimmel.
'Yes your lips are very moist,' replied Charlie inexplicably.
The Two And A Half Men star, 45, then gave Kimmel a mug with a picture of a fox wonkily taped to the outside. 'I'll let you figure it out my man,' added Charlie before he ran off set. 'I gotta go,' he shouted as he disappeared into the wings.