The sprawling, five-bedroom property is on the market for a whopping $7.2 million USD [£4.4 million GBP pounds].
The 7,924 square foot home boasts seven bathrooms, a spa and a pool.
A real estate listing for the mansion reads: 'Spectacular celebrity home! This custom-built Mediterranean house in Mulholland Estates is an entertainer's dream with spacious public rooms, most of which open to a beautifully landscaped yard featuring a professional outdoor kitchen with dining area, pool and spa.
'Other features include a screening room and top-of-line appliances and finishes.'
Wall Street star Sheen, 45, paid ex-wife Brooke Mueller $1 million USD to become the sole owner of the home in their divorce proceedings earlier this year.
Money magazine Forbes estimates that Sheen has earned $40 million USD in the last 12 months - despite getting sacked as the highest paid actor on TV for his role in sitcom Two And A Half Men.