The 52-year-old House star said that when the series comes to an end, he'll probably give up TV work and step behind the camera instead.
'I think I have been rather spoiled here,' he said of the show.
'I can't imagine there will be another one quite like this. I think I will probably be as interested by either writing or producing or directing, or some other aspect. I find the whole field of it fascinating.
'And I think I am extremely lucky to have had the one shot that I have had at it and I wouldn't go looking for lightning to strike twice.'
As the son of a real-life doctor, Laurie says he has a great respect for the power of medication.
'I have always rather stuck up for Western medicine against people who are suspicions of men in white coats,' he told the Daily Record.
'People say, 'They are all out to get us. It's all a con. Doctors tell you this, but if you eat more celery...'
Three-quarters of us would not be here were it not for antibiotics.
'That's just an undeniable truth - in fact probably more than three-quarters.
'And you can chew all the celery you want, that is just a fact. We wouldn't be here.
'There would be empty chairs.
'It's a chilling thought that we owe our survival, and certainly the length of our survival to Western medicine.
'So I am a defender and I believe in it and I applaud it.'