The 30-year-old X Factor judge will join stars such as Jessie J, N-Dubz star Dappy and Tinchy Stryder.
The tour will take place in four cities - Manchester, Birmingham, Bristol and London - from Monday November 28, 2011, to Thursday December 1, 2011.
Rowland will perform on the final date at the Brixton Academy in London she revealed live on BBC Radio One.
Rowland performed at the first 1Xtra Live event in 2008 in Coventry.
Speaking about the event, she said: 'I loved performing at the first ever 1Xtra Live four years ago and I'm really happy to be headlining the final date of this incredible event.
'There's so much amazing talent on the line-up and I'm proud to be a part of it.'