The British rocker, 62, said he took so much of the hallucinogenic drug during his Black Sabbath days that he often gets flashbacks, which leave him feeling anxious.
He said: “I still get the after-effects of LSD to this day.
“I call them my ‘wobblers’.
“In a flash, every little problem freaks me out and becomes the end of the world.”
Birmingham-born Osbourne, who has been sober for several years, told a US magazine: “In my experience, LSD is great until it isn’t.
“One minute, you’re running down Miami Beach with a foam finger on your head, the next you’re sticking a gun in your best friend’s face.”
He added: “If you keep taking that s***, it’s going to bite you on the balls.”