The 68-year-old veteran actress will star with Rogen in the road-trip comedy movie with The Proposal's director Anne Fletcher taking the helm.
According to The Hollywood Reporter, the movie follows an inventor, played by Rogen, who invites his mum on a road trip as he tries to sell his new invention, during which she reunites with a long-lost love.
Dan Fogelman will write the script based on his own experiences with his mother and Lorne Michaels, John Goldwyn and Evan Goldberg will produce.
Shooting is scheduled to begin in the spring.