The 47-year-old British singer has booked the Royal Opera House in London for his show on Sunday, November 6, and all proceeds will go to the Sir Elton John AIDS Foundation's newly created Elizabeth Taylor Memorial Fund.
In a statement, Michael said, 'I have seen how HIV can affect people's lives, how it can destroy families and communities.
'The way that the Elton John AIDS Foundation gets help to the people around the world who need it most - often the most marginalised communities - really spurred me on to do something.'
Sir Elton responded, 'George has been a patron of the Foundation since its inception and has been a much valued supporter over the years, as well as a dear friend. This is an incredible and generous gesture. I thank George from my heart for doing this. His is an amazing talent, and this is a fantastic gift he is making to people affected by HIV.'
Taylor was a staunch campaigner against the disease following the death of friend Rock Hudson in 1985, and subsequently launched the American Foundation for Aids Research (Amfar).
The show will form part of George's 47-date European tour.