The American comedian - best known for playing himself in TV sitcom 'Seinfeld' - will receive the huge sum for the 90-minute set at The O2 Arena next year.
It will be the 56-year-old comic star's first show in the UK capital for 12 years and tickets to see Jerry - who is the world's richest comedian, having earned £9 million per episode of 'Seinfeld' - on June 3 are on sale for up to £110 each.
He last told jokes in London at the Palladium in 1998, with tickets for the date selling out in less than 30 minutes.
The married father-of-three - who claims he is preparing for his routine by drinking "lots and lots of rocket fuel Stumptown coffee" - is looking forward to performing at the venue where so many of his comedy peers have performed.
He quipped: "The O2 is a pretty big place. I've heard great things about it from my good friends Chris Rock and Ricky Gervais and, who's that other fella? The tall skinny one ... Russell Brand. But I prefer old theatres because the audience is more ... trapped.
"Laughter never goes out of fashion. It's like magic, it can get you anything - money, women, houses, cars. Anything.
"Never underestimate the power of humour. It opens doors."