The 32-year-old actress plays assassinated US President John F. Kennedy's wife Jackie in the show, titled The Kennedys, which had been destined for the cable channel until TV bosses announced that they considered it, 'not a fit for the History brand'.
It has been reported that the surviving members of the Kennedy family were unhappy with the finished product, and branded it 'historically inaccurate'.
And Holmes said that while she made sure that she kept well out of the politics of the show, she was still taken aback to hear it had been dropped.
She told Access Hollywood, 'When I heard about The History Channel not airing this, I was as shocked as everybody else. I didn't realise that was coming. I kind of just stayed out of it.
'I had a wonderful time doing this job and playing the character and, you know, it's up to the producers after that.
'We wanted to treat it as respectfully as possible and that's how we felt about this whole series. We really wanted to honour these people and do the best work that we could.'
The show was snapped up by bosses at America's ReelzChannel and will air in April.