The 30-year-old reality star posted a message on her Twitter page today during an afternoon of testimony in the high-profile case, which is being streamed live on US TV.
Orlando woman Casey Anthony is accused of allegedly killing her toddler daughter Caylee Anthony in the summer of 2008.
Seemingly incredulous at the day's events, Kardashian asked her fans: 'Who is into this Casey Anthony case? So many theories and stories. This is a mess! Who do you believe? Who is lying here?'
She continued: 'What a crazy testimony today! Casey's mum says one thing and her son says the opposite. Someone is lying here!'
The newly-engaged star ended her tweet by saying: 'I believe Casey is guilty, but there's [sic] so many conflicting stories raising so much reasonable doubt – I feel this will be a shocking outcome.'
The Kourtney & Kim Take New York star, whose late father was famous Hollywood lawyer Robert Kardashian, has previously said that she likes to take an interest in high-profile legal battles.