The 18-year-old singer and actress will compete for honours in three categories, Favourite TV Actress - which she will contest with Miranda Cosgrove, Selena Gomez and Victoria Justice - Favourite Singer, and Favourite Movie Actress.
In the musical category, the 'Party in the USA' hitmaker faces competition again from Selena Gomez, as well as Katy Perry and Taylor Swift, while Ashley Judd, Kristen Stewart and Emma Watson are also up for Favourite Movie Actress.
Elsewhere, in the film honours, 'The Karate Kid' is up for three awards,including Favourite Movie, Favourite Movie Actor for its star Jaden Smith and Favourite Butt-kicker for Jackie Chan.
'Toy Story 3' and 'Shrek Forever After' will go head-to-head in two categories, with both up for Favourite Animated Movie and 'Toy Story's Tim Allen and Tom Hanks competing with 'Shrek's Eddie Murphy and Cameron Diaz in the Favourite Voice from an Animated Movie group.
Cameron - who voices Princess Fiona - told People: "Well, as everyone knows, the kids know their stuff, so I'm always very flattered to be their choice for anything. After all these years, Fiona is very close to my heart and
it's awesome to know that kids around the world love her as much as I do."
Other notable categories include the Favourite TV Actor, which sees brothers Joe and Nick Jonas compete against twins Dylan and Cole Sprouse for the honour.
Comic Jack Black returns to host the ceremony for a third time.
Voting for the awards opens on March 7.
The Nickelodeon's 2011 Kids' Choice Awards take place at the Galen Centre in Los Angeles on April 2.
Nickelodeon's 2011 Kids' Choice Awards nominees:
Television:
Favourite TV Show:
'Big Time Rush'
'iCarly'
'The Suite Life on Deck'
'Wizards of Waverly Place'
Favourite Reality Show:
'American Idol'
'America's Funniest Home Videos'
'America's Got Talent'
'Wipeout'
Favourite TV Actor:
Joe Jonas
Nick Jonas
Cole Sprouse
Dylan Sprouse
Favourite TV Actress:
Miranda Cosgrove
Miley Cyrus
Selena Gomez
Victoria Justice
Funniest TV Sidekick:
David Henrie
Jennette McCurdy
Noah Munck
Brenda Song
Favourite Cartoon:
'The Penguins of Madagascar'
'Phineas & Ferb'
'Scooby Doo! Mystery Incorporated'
'SpongeBob SquarePants'
Sports:
Favourite Male Athlete:
Peyton Manning
Shaquille O'Neal
Michael Phelps
Shaun White
Favourite Female Athlete:
Danica Patrick
Lindsey Vonn
Serena Williams
Venus Williams
Film:
Favourite Movie:
'Alice in Wonderland'
'Diary of a Wimpy Kid'
'Harry Potter and the Deathly Hallows: Part 1'
'The Karate Kid'
Favourite Movie Actor:
Jack Black ('Gulliver's Travels')
Johnny Depp ('Alice in Wonderland')
Dwayne Johnson ('Tooth Fairy')
Jaden Smith ('The Karate Kid')
Favourite Movie Actress:
Miley Cyrus ('The Last Song')
Ashley Judd ('Tooth Fairy')
Kristen Stewart ('The Twilight Saga: Eclipse')
Emma Watson ('Harry Potter and the Deathly Hallows: Part 1')
Favourite Animated Movie:
'Despicable Me'
'How to Train Your Dragon'
'Shrek Forever After'
'Toy Story 3'
Favourite Voice from an Animated Movie:
Tim Allen ('Toy Story 3')
Cameron Diaz ('Shrek Forever After')
Tom Hanks ('Toy Story 3)
Eddie Murphy ('Shrek Forever After')
Favourite Butt-Kicker:
Steve Carell ('Despicable Me')
Jackie Chan ('The Karate Kid')
Robert Downey Jr. ('Iron Man 2')
Will Ferrell ('Megamind')
Music:
Favourite Music Group:
Big Time Rush
Black Eyed Peas
Jonas Brothers
Lady Antebellum
Favourite Male Singer:
Justin Bieber
Bruno Mars
Jay-Z
Usher
Favourite Female Singer:
Miley Cyrus
Selena Gomez
Katy Perry
Taylor Swift
Favourite Song:
'Baby' by Justin Bieber, featuring Ludacris
'California Gurls' by Katy Perry, featuring Snoop Dogg
'Hey, Soul Sister' by Train
'Mine' by Taylor Swift
Other Categories:
Favourite Book:
'Diary of a Wimpy Kid' series
'Dork Diaries'
'Vampire Academy' series
'Witch and Wizard' series
Favourite Videogame:
'Just Dance 2'
'Mario vs. Donkey Kong: Mini-Land Mayhem'
'Need for Speed: Hot Pursuit'
'Super Mario Galaxy 2'