The 34-year-old star is engaged to Hollywood agent Jim Toth, 40, and already has two children - Ava, 11, and Deacon, seven - from her marriage to actor Ryan Phillippe.
Asked if she will have more children, she said: 'I would love to have more kids. My children are the best part of my day.'
The actress has dated stars such as Phillippe and Jake Gyllenhaal and said she has been lucky to have another shot.
She said to UK's Closer magazine: 'I am lucky I've had a few shots getting second chances. That's nice. I thought I knew everything about love and relationships in my 20s - the ignorance of youth is bliss.
'As you get older, you start to realise that you don't really know anything and life is a great travelling journey. Life is unexpected - you just never know what's going to happen.'