The newlywed and hubby Jim Toth were spotted at Belize airport on April 4, heading for a romantic trip with Ava, 11, and Deacon, seven, in tow.
Witness Paul Schmidt told Us Weekly, 'Reese held her kids' hands and rushed through the airport.'
The couple and Reese's kids, who she had during a previous marriage to Ryan Phillippe, reportedly stayed in two of director Francis Ford Coppola's luxury resorts - where a two-bedroom pavilion costs $1,850 per night.
'They were so low-key,' said a second onlooker. 'Most people didn't even know who they were.'