The 36-year-old actress presented Jen with ELLE's 18th Annual Women in Hollywood Tribute at the Four Seasons Hotel in Beverly Hills on Monday, where she praised the Friend's star's 'combination of sex appeal and complete lovabililty'.
'You just want to get your nails done with her, and you want to make out with her at the same time… at least I do,' Reese said according to Us Weekly.
'First we get our nails done, then we make out,' she joked. 'It's totally awesome. That's because she's MY friend, not yours!'
She revealed how she first bonded with Jen, 42, when she made a guest appearance in Friends as her on-screen little sister back in 1999.
'I just had a baby [daughter Ava, now 12] and I could not stop watching Friends,' she explained. 'I was super duper excited y'all!
'In all my enthusiasm, I completely forgot something crucial... I had never been on television in front of a live audience ever in my entire life. And I panicked! I totally froze!
'I couldn't remember my lines and the writers were yelling... I just stood there absolutely completely frozen.'
The Jen came to the rescue, asking her, 'Hey, are you okay? You're kind of freaking me out.'
'[She said], 'You're going to make a mistake and you're going to flip your line and whatever and the audience is going to love it',' Witherspoon recalled. ''Don't try to be perfect, just try to be yourself.'
'That's the story that sort of captured Jen the best for me. On one hand, she is this gorgeous breath-taking beauty that men lose their thought process and their speech patterns [over]. And, on the other hand, she is a woman who lets you in.'