The Princess Diaries actress and Andrews could be reuniting for an upcoming episode of the musical-comedy, according to reports.
Dame Julie, 75, is in negotiations to play the grandmother of Chris Colfer's character Kurt Hummel, while Anne, 28, could reportedly be starring as his aunt.
Hathaway recently admitted on US chat show Late Night with Jimmy Fallon to already having cast herself a part on the US TV show.
She said: 'In my head, I've cast myself in Glee and I know what song I'm going to sing! I would wanna play Kurt's long-lost aunt's mother's sister who is also gay, who comes back to help him deal with his sexuality, and I would sing You Are Not Alone from Stephen Sondheim's epic show Into the Woods.'