The X-Factor judge, who recently divorced cheating husband Ashley Cole, revealed that even co-stars Simon Cowell and Louis Walsh "do her head in".
Speaking to Radio 1, Cheryl, 27, said, "You go through periods where they're doing my head in and this week it's Louis. Louis does my head in sometimes, but I love him.
"I relate to girls a lot more than I do boys.
"I'm not one of those sorts of girls. I just don't get boys, I don't really get men."
But she said that it is friend and mentor Simon who winds her up the most.
"Out of everybody on that panel, he's the one person who can't tell me I look orange. He knows which buttons to press," she explained.
"Sometimes I think maybe I shouldn't bite back but I do, especially because I've got four girls to defend."