The 27-year-old X Factor judge, who is rumoured to be dating the US dancer, joined Hough’s mum and stepfather for dinner.
Cole reportedly looked happy chatting to Marriann Nelson and her husband Aaron at the Soho House in Los Angeles.
Hough's sister Julianne and her boyfriend, American Idol host Ryan Seacrest, also attended the celebration of Marriann's 54th birthday, along with Cole’s brother Gary.
A Soho House source told UK newspaper, the Daily Mirror: 'Cheryl was shy at first, but soon warmed up as she chatted with Derek’s mum and dad.
'She was overheard saying she was looking forward to spending a lot more time with them when she moved to LA. She said she knew it would be tough for her being so far away from her loved ones when she starts living in America, so she hoped that she could count on Derek's family to fill that void.”
The source added: 'Derek's mother and father looked very taken with Cheryl, and his mum spent a fair amount of time locked in conversation with her.'