The Flood singer's record Messy Little Raindrops is in the running to win the category.
Half a million people have voted for the 27-year-old Girls Aloud star, who is up against Justin Bieber, 16, in the category.
The Jonas Brothers and JLS have been placed in the worst band section.
Pop star Lady Gaga, WikiLeaks founder Julian Assange and US rapper Kanye West are pitted against each other for the hero of the year award.
X Factor boss Simon Cowell has been nominated as villain of the year, with competition from Prime Minister David Cameron and Deputy Nick Clegg.
The winners will be announced at London's 02 Academy in Brixton on February 23.