The Sex And The City actress is set to start working on new film I Don't Know How She Does It. She said that she 'could die' thinking about how it will force her to spend time away from eight-year-old son James Wilkie, and 17-month-old twin daughters Loretta and Tabitha.
The 45-year-old, who is married to Matthew Broderick, told Elle magazine, 'Even now I think about the separation and it makes my stomach hurt. I think about my son waking up on his birthday without me there, and I could die.'
The couple used a surrogate mother to have the twins, and she admitted she was taken aback the first time she saw them.
'Everything was suspended,' she said. 'I can't even tell you what other sounds were in the room. I loved them immediately.
'They looked surprisingly different from James Wilkie, which I wasn't expecting.'